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Nucleotide receptors on DDT1 MF-2 vas deferens cells
L Van der Zee1, A Nelemans, A Den Hertog
1Department of Pharmacology/Clinical Pharmacology, University of Groningen, Netherlands.
European Journal of Pharmacology
|May 14, 1992
Abstract:
On exposure to triphosphatic nucleotides vas deferens DDT1 MF-2 smooth muscle cells responded with an outward K+ current as measured with the whole-cell patch clamp configuration. The rank order of potency was: ATP greater than UTP greater than TTP greater than CTP = GTP. The responses evoked by these agonists were blocked by suramin. Adenosine, ADP, alpha, beta-methylene-ATP and 2-methylthio-ATP did not affect the transmembrane current. The responses evoked by the nucleotides in DDT1 MF-2 cells are supposed to be mediated via 'nucleotide' receptors.