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Are we seeking the correct targets for therapeutic intervention?
1Department of Experimental Pathology, William Harvey Research Institute, Saint Bartholomews Hospital Medical College, London.
International Journal of Tissue Reactions
|January 1, 1992
Summary
This review explores rheumatoid arthritis treatments, focusing on managing inflammation and preventing joint destruction. Future therapies aim for remission using advanced molecular techniques and chronic disease models.
Area of Science:
- Rheumatology
- Immunology
- Molecular Biology
Background:
- Rheumatoid arthritis (RA) involves complex physiological development and chronic inflammation.
- Current treatments focus on palliative care for acute inflammation and inhibiting tissue destruction.
- Understanding autoimmunity and immune system manipulation is key to RA management.
Purpose of the Study:
- To review current understanding and future directions in rheumatoid arthritis therapy.
- To discuss the manipulation of the eicosanoid pathway and immunotherapy strategies.
- To highlight the importance of chronic disease models for therapeutic assessment.
Main Methods:
- Review of physiological development of rheumatoid arthritis.
- Discussion of eicosanoid pathway manipulation and immunotherapy.
- Analysis of intercellular adhesion, tolerance induction, and novel immunomodulatory agents.
Main Results:
- Palliative treatment of acute inflammation will remain necessary.
- Improved selectivity and tolerability of anti-inflammatory agents are ongoing.
- Long-term RA management requires targeting chronic inflammatory mechanisms.
Conclusions:
- Future RA therapy will leverage molecular biology for precise immune system manipulation.
- Achieving remission in rheumatoid arthritis is an attainable goal.
- Long-term chronic models are crucial for evaluating novel therapeutic strategies.
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