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Shared antigenic epitopes of the major core proteins of human and simian immunodeficiency virus isolates
J R Higgins1, S Sutjipto, P A Marx
1Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Journal of Medical Primatology
|July 1, 1992
Abstract:
Antigenic epitopes on the major core (gag) protein of isolates of simian and human immunodeficiency virus (SIV and HIV) were compared using a panel of eleven mouse monoclonal antibodies (Mabs) that recognized nine distinct gag epitopes. Viral isolates used for comparison were HIV-1IIIb, HIV-2ROD, and SIV isolates from macaque (SIVmac), sooty mangabey (SIVsm-UCD), African green monkey (SIVagm), and stump-tailed macaque (SIVstm-UCD). The relatedness of the various HIV and SIV isolates, as determined by Mabs to core protein epitopes, paralleled that ascertained by genetic sequencing.