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Structural basis of the in vivo induction of micronuclei
W L Yang1, G Klopman, H S Rosenkranz
1Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Mutation Research
|October 1, 1992
Abstract:
The structural basis of the in vivo induction of micronuclei was examined with CASE, a structure-activity relational method. The CASE program identified a number of structures associated with this activity. When used to predict the activity of chemicals not included in the learning set, these structural determinants gave a concordance in excess of 83%. The existence of a structural basis for the induction of micronuclei will permit an investigation of the mechanistic basis of this phenomenon.