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Related Experiment Videos

Spatial pattern of receptor expression in the olfactory epithelium.

P Nef1, I Hermans-Borgmeyer, H Artières-Pin

  • 1Laboratory for Molecular Neurobiology, Salk Institute, La Jolla, CA 92186-5800.

Proceedings of the National Academy of Sciences of the United States of America
|October 1, 1992
PubMed
Summary

Researchers identified a novel olfactory receptor, OR3, in mice using PCR. This seven-transmembrane-domain receptor is expressed in specific olfactory cells during development and in adulthood, suggesting roles in odor coding or olfactory system development.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Olfaction relies on a diverse array of olfactory receptors (ORs) within the seven-transmembrane-domain receptor superfamily.
  • Understanding the expression patterns of specific ORs is crucial for deciphering olfactory coding and neural development.

Purpose of the Study:

  • To isolate and characterize novel olfactory receptors in mice using a PCR-based approach.
  • To investigate the expression pattern of the identified receptor (OR3) during olfactory system development and in the adult olfactory epithelium.

Main Methods:

  • Employed a PCR-based strategy to amplify putative olfactory receptors.
  • Utilized in situ expression analysis to determine the developmental and spatial expression of the OR3 receptor.

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Main Results:

  • Successfully isolated a novel seven-transmembrane-domain receptor, designated OR3, from murine olfactory tissues.
  • OR3 expression was first detected in cells near the telencephalic vesicle wall at embryonic day 10.
  • In adult olfactory epithelium, OR3 exhibited unique expression in a subset of olfactory cells with bilateral symmetry.

Conclusions:

  • The OR3 receptor represents a newly identified component of the murine olfactory system.
  • Its specific spatiotemporal expression pattern suggests a potential functional role in either odor coding or the developmental processes of the olfactory system.