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Related Experiment Videos

Dopaminergic and serotonergic function following isolation rearing in rats: study of behavioural responses and

G H Jones1, T D Hernandez, D A Kendall

  • 1Department of Experimental Psychology, University of Cambridge, UK.

Pharmacology, Biochemistry, and Behavior
|September 1, 1992
PubMed
Summary
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Rats reared in isolation exhibit altered locomotor activity and changes in dopamine and serotonin function, particularly in brain regions like the nucleus accumbens. These neurochemical differences may underlie behavioral disturbances observed in isolation-reared rodents.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Neurochemistry

Background:

  • Social isolation in early life is a significant environmental factor impacting brain development and behavior.
  • Understanding the neurobiological underpinnings of isolation-induced behavioral changes is crucial for addressing related disorders.

Purpose of the Study:

  • To investigate the effects of isolation rearing on locomotor activity, behavioral stereotypy, and monoamine function in rats.
  • To compare neurochemical alterations in both postmortem and in vivo conditions.

Main Methods:

  • Rats were reared in isolation or social conditions.
  • Locomotor activity and stereotyped behaviors were assessed after administration of d-amphetamine sulphate and apomorphine hydrochloride.
  • Postmortem monoamine concentrations and in vivo extracellular monoamine levels (using intracerebral dialysis) were measured.

Related Experiment Videos

  • Postsynaptic dopamine receptor function was evaluated in brain tissue slices.

    • Main Results:

    • Isolation-reared rats displayed altered locomotor responses to amphetamine and differential sensitivity to apomorphine.
    • Postmortem analysis revealed higher dopamine concentrations and altered dopamine asymmetry in the medial prefrontal cortex of isolates.
    • In vivo studies showed exaggerated dopamine release and reduced DOPAC levels in response to amphetamine in isolates.
    • Isolates exhibited a reduced 5-hydroxyindoleacetic acid/serotonin ratio in the nucleus accumbens.

    Conclusions:

    • Isolation rearing significantly alters monoamine systems, particularly dopamine and serotonin pathways, in specific brain regions.
    • These neurochemical changes correlate with observed behavioral alterations, suggesting a neurobiological basis for isolation-induced behavioral disturbances.
    • The findings highlight the long-lasting impact of early-life social environment on brain function and behavior.