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Updated: Feb 10, 2026

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Chemical Triphosphorylation of Oligonucleotides
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Exploiting the chemical synthesis of RNA
1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Trends in Biochemical Sciences
|September 1, 1992
Abstract:
A number of nucleotide phosphoramidites are now available that permit the chemical synthesis of RNA, modified RNA and RNA-DNA chimeric oligonucleotides. Since the chemical strategy allows the introduction of a particular modification at any given site in a nucleotide polymer, very subtle and specific questions regarding structure-function relationships in RNA may be addressed.
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