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Secretory meningioma associated with numerous meningothelial rosettes
1Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.
Abstract:
A case of secretory meningioma with numerous meningothelial rosettes is reported. A 66-year-old man with moyamoya disease gradually developed skull deformity, and underwent surgery for the skull tumor overlying the hemisphere. Histological examination disclosed numerous meningothelial rosettes quite similar to those induced by subarachnoid injection of epinephrine and pseudopsammoma bodies described by Kepes. This may be the first case of meningioma associated with numerous rosette formations.
Insights
This report details a rare secretory meningioma case in a man with moyamoya disease. The tumor displayed numerous meningothelial rosettes, a unique histological finding potentially linked to specific stimuli.
Area of Science:
- Neuropathology
- Neurosurgery
- Oncology
Background:
- Moyamoya disease is a cerebrovascular disorder characterized by progressive stenosis of intracranial arteries.
- Meningiomas are tumors arising from the meninges, the membranes surrounding the brain and spinal cord.
- Secretory meningiomas are a subtype characterized by the presence of psammoma bodies and glandular differentiation.
Observation:
- A 66-year-old male patient with moyamoya disease presented with progressive skull deformity.
- Surgical intervention was performed for a skull tumor located over the cerebral hemisphere.
- Histological examination revealed numerous meningothelial rosettes and pseudopsammoma bodies.
Findings:
- The case presents a secretory meningioma with an unusually high number of meningothelial rosettes.
- The observed rosettes bear resemblance to those induced by subarachnoid epinephrine injection and described by Kepes.
- This represents a potentially novel histological presentation of meningioma.
Implications:
- This finding expands the histological spectrum of meningiomas, particularly secretory subtypes.
- Understanding the formation of these rosettes may offer insights into meningioma pathogenesis.
- Further research is warranted to explore the etiological factors and clinical significance of such rosette formations in meningiomas.