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Related Experiment Videos

Pseudomembranous and membranous conjunctivitis. Immunohistochemical features.

T Kivelä1, K Tervo, E Ravila

  • 1Department of Ophthalmology, Helsinki University Central Hospital, Finland.

Acta Ophthalmologica
|August 1, 1992
PubMed
Summary

Sulfasalazine can cause Stevens-Johnson syndrome, leading to severe eye inflammation and membranes. Surgical removal of these membranes may reduce scarring and complications.

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Area of Science:

  • Ophthalmology
  • Dermatology
  • Rheumatology

Background:

  • Sulfasalazine is a medication used to treat inflammatory conditions.
  • Stevens-Johnson syndrome is a rare, serious disorder affecting skin and mucous membranes.

Observation:

  • A 63-year-old man on sulfasalazine developed Stevens-Johnson syndrome with severe stomatitis and necrotizing pseudomembranous conjunctivitis.
  • Conjunctival membranes formed, requiring surgical removal, and corneal erosion was present.

Findings:

  • Histopathology of membranes showed polymorphonuclear leukocytes, fibrin, tenascin, and fibronectin.
  • Post-acute care revealed conjunctival scarring, punctate keratitis, dry eye, and irregular astigmatism, but preserved visual acuity and ocular function.

Implications:

Related Experiment Videos

  • Surgical debridement of conjunctival membranes may prevent secondary infections, fibrosis, and symblepharon.
  • This procedure might decrease, not increase, conjunctival scarring after necrotizing conjunctivitis.