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Related Experiment Videos

Comparison between cetirizine and terfenadine: time-response study.

L Randazzo1, M Valencia, A Olivé-Pérez

  • 1Hospital de la Santa Cruz y San Pablo, Unidad de Alergia, Barcelona, España.

Allergologia Et Immunopathologia
|May 1, 1992
PubMed
Summary

Cetirizine 10 mg demonstrated superior efficacy over terfenadine 60 mg in inhibiting histamine-induced skin reactions. Cetirizine offered a longer duration of action and greater inhibition, indicating its enhanced peripheral antihistaminic effect.

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Area of Science:

  • Pharmacology
  • Dermatology
  • Clinical Trials

Background:

  • First-generation H1 antagonists are associated with anticholinergic side effects and sedation.
  • Second-generation antihistamines like cetirizine and terfenadine aim to reduce these adverse effects.
  • Understanding the comparative efficacy and duration of action of these drugs is crucial for clinical practice.

Purpose of the Study:

  • To compare the onset and duration of peripheral antihistaminic effects of cetirizine 10 mg and terfenadine 60 mg.
  • To evaluate the cutaneous activity inhibition of histamine-induced responses.
  • To assess the tolerability and side effect profile of both drugs.

Main Methods:

  • A double-blind, placebo-controlled study involving six healthy volunteers.

Related Experiment Videos

  • Intradermal histamine injections at various time points post-drug administration.
  • Measurement of histamine-induced wheal and flare response using planimetry.
  • Assessment of drug tolerability and side effects.

    • Main Results:

    • Both cetirizine and terfenadine were well-tolerated with no reported anticholinergic side effects or sedation.
    • At 30 minutes post-administration, no significant difference in histamine response inhibition was observed.
    • From 30 minutes up to 24 hours, cetirizine demonstrated significantly greater inhibition compared to terfenadine.
    • Cetirizine reached maximal effect at 180 minutes, while terfenadine reached it at 240 minutes, with both maintaining maximal effect until 480 minutes.

    Conclusions:

    • Cetirizine 10 mg exhibits a more potent and sustained peripheral antihistaminic effect compared to terfenadine 60 mg.
    • Both drugs are well-tolerated, but cetirizine offers superior efficacy in managing histamine-mediated cutaneous responses.
    • These findings support cetirizine as a potentially more effective option for conditions requiring prolonged antihistaminic activity.