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Malignant eccrine spiradenoma. A clinicopathologic study.

Z B Argenyi1, A V Nguyen, K Balogh

  • 1Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City 52242-1009.

The American Journal of Dermatopathology
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

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Malignant eccrine spiradenomas (MES) are rare skin tumors. This study details two cases, highlighting variable cytodifferentiation and the importance of identifying associated benign tumors for diagnosis.

Area of Science:

  • Dermatopathology
  • Oncology
  • Histopathology

Background:

  • Malignant eccrine spiradenomas (MES) are rare cutaneous neoplasms.
  • Their immunohistochemical and ultrastructural characteristics remain incompletely understood.

Observation:

  • Two cases of MES were investigated, with one undergoing detailed immunohistochemical and ultrastructural analysis.
  • Patient 1 presented with multiple benign spiradenomas and cylindromas, alongside malignant changes.
  • Patient 2 exhibited a cystic mass with both benign spiradenoma and malignant features, including squamous and glandular differentiation.

Findings:

  • Malignant areas in MES showed disrupted architecture, absence of dual cell populations, and high mitotic activity.
  • Immunohistochemistry confirmed eccrine differentiation in the malignant components.

Related Experiment Videos

  • Cytodifferentiation in MES can be highly variable, sometimes leading to a near-complete loss of eccrine markers.

    • Implications:

    • This is potentially the first report of MES associated with multiple spiradenomas and cylindromas.
    • Diagnosing MES may necessitate identifying adjacent benign spiradenomas.
    • A history of long-standing skin lesions with recent rapid growth should prompt tissue diagnosis for MES.