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The complement system in human reproduction.

O A Vanderpuye1, C A Labarrere, J A McIntyre

  • 1Center for Reproduction and Transplantation Immunology, Methodist Hospital of Indiana, Inc., Indianapolis.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|April 1, 1992
PubMed
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Reproductive tissues uniquely manage allogeneic interactions, requiring complement regulators like membrane cofactor protein (MCP) and decay accelerating factor (DAF) to prevent damage and ensure success.

Area of Science:

  • Immunology
  • Reproductive Biology

Background:

  • Reproductive tissues naturally engage in allogeneic interactions, necessitating mechanisms to prevent complement-mediated damage.
  • Allogeneic extraembryonic membranes and semen must avoid complement attack for successful reproduction.

Purpose of the Study:

  • To review the role of complement system regulators in reproductive allogeneic interactions.
  • To identify areas for further research on complement regulation in reproduction.

Main Methods:

  • Review of existing literature on complement system components and regulators in reproductive tissues.
  • Analysis of the expression and function of complement regulatory proteins (MCP, DAF, CD59) in reproductive contexts.

Main Results:

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  • Membrane glycoproteins (MCP, DAF, CD59) are expressed on trophoblast and amniotic epithelium, protecting against complement damage.
  • Reproductive tract fluids generally have lower complement levels than blood, with hormonal regulation of C3 in endometrium and cervix.
  • Oocytes lack MCP; sperm express MCP and DAF in specific regions. Seminal plasma contains MCP and SP-40,40, but not DAF.

    • Conclusions:

    • Complement regulators are crucial for safeguarding reproductive tissues from immune attack.
    • The distribution and potential alternative functions of complement regulators in reproductive fluids and cells warrant further investigation.