Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

15.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
15.8K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

2.8K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
2.8K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.4K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.4K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.5K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.5K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

2.8K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Parent-into-F1 Model of Graft-vs-Host Disease as a Model of In Vivo T Cell Function and Immunomodulation.

Current medicinal chemistry. Immunology, endocrine & metabolic agents·2009
Same author

Therapeutic potential of CD8+ cytotoxic T lymphocytes in SLE.

Autoimmunity reviews·2008
Same author

In vivo neutralization of TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL.

Journal of immunology (Baltimore, Md. : 1950)·2001
Same author

Spontaneous formation of germinal centers in autoimmune mice.

Journal of leukocyte biology·2001
Same author

Telomeres, telomerase, and lupus: the long and short of it.

Clinical immunology (Orlando, Fla.)·2001
Same author

Lessons from animal models of vasculitis.

Current rheumatology reports·2000
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Related Experiment Videos

T-cell and B-cell function in lupus.

C S Via1, B S Handwerger

  • 1University of Maryland School of Medicine, Baltimore.

Current Opinion in Rheumatology
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Systemic lupus erythematosus (SLE) involves B-cell hyperactivity, often driven by T-cells. Research explores the T-cell activation paradox and intrinsic B-cell abnormalities, especially in CD5+ B cells, for lupus insights.

Related Experiment Videos

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Background:

  • B-cell hyperactivity is a hallmark of systemic lupus erythematosus (SLE).
  • T-cell dysregulation is implicated as a key driver of B-cell hyperactivity in SLE.
  • A paradox exists between observed in vivo T-cell activation and in vitro T-cell functional depression.

Purpose of the Study:

  • To investigate the complex interplay between T-cells and B-cells in the pathogenesis of lupus.
  • To explore the reasons behind the contradictory findings in T-cell function assays.
  • To examine the potential contribution of intrinsic B-cell defects to lupus pathology.

Main Methods:

  • Analysis of T-cell activation markers in lupus patients.
  • In vitro functional assays to assess T-cell responses.
  • Characterization of B-cell subsets, including CD5+ B cells, in lupus.

Main Results:

  • Evidence supports T-cell driven B-cell hyperactivity in a significant portion of lupus cases.
  • The discrepancy between in vivo and in vitro T-cell function requires further elucidation.
  • Intrinsic abnormalities in B-cells, particularly CD5+ B cells, are under active investigation for their role in SLE.

Conclusions:

  • Understanding T-cell and B-cell interactions is crucial for lupus pathogenesis.
  • Further research is needed to resolve the T-cell activation paradox in lupus.
  • Intrinsic B-cell abnormalities may represent a novel therapeutic target in lupus treatment.