[Effects of flavobion on nucleic acids in tissues of rats irradiated with gamma rays]

Flavobion /SPOFA/ is a hepatoprotective preparation containing an effective constituent--the flavonoids, namely, silybin, silydianin and silychristin, collectively referred to as silymarin. Silymarin can influence certain metabolic processes including RNA synthesis and stabilize cell membranes. Suspension of this preparation was given p. o. by tube in a dose of 70 mg/kg, one hour before whole-body irradiation with a 5.7 Gy dose of gamma radiation (60Co). Animals were subjected to partial hepatectomy/by 30 min. after irradiation/and examined on hour 30 after operation. The changes in concentration and total content of RNA and DNA in the liver (both intact and regenerating), spleen and bone marrow were followed. We found that Flavobion administration influenced the concentration and total content of RNA and DNA in the spleen and bone marrow. However, in a target organ, liver, changes in nucleic acids were less pronounced.