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Related Experiment Videos

Pediatric leukemia/lymphoma with t(8;14)(q24;q11).

B J Lange1, S C Raimondi, N Heerema

  • 1Division of Oncology, Children's Hospital of Philadelphia, PA 19104.

Leukemia
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

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The t(8;14)(q24;q11) translocation in pediatric T-cell acute lymphoblastic leukemia (T-ALL) is linked to aggressive disease. This specific leukemia subtype presents with high tumor burden and poor survival outcomes.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Chromosomal translocations are common in pediatric T-cell acute lymphoblastic leukemia (T-ALL).
  • The t(8;14)(q24;q11) translocation involves the T-cell receptor alpha/delta locus, but its clinical significance remains undefined.

Purpose of the Study:

  • To clinically define the disease associated with the t(8;14)(q24;q11) chromosomal translocation in pediatric leukemia/lymphoma.
  • To analyze the prevalence, clinical characteristics, and outcomes of this specific T-ALL subtype.

Main Methods:

  • Retrospective analysis of fifteen pediatric cases with t(8;14)(q24;q11) from literature and institutional records.
  • Characterization of clinical features, immunophenotype, and survival data.
  • Establishment and analysis of seven cell lines from six cases.

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Main Results:

  • The t(8;14)(q24;q11) translocation accounts for approximately 1% of pediatric ALL cases.
  • Associated disease shows male predominance, median age of 5.5 years, high white blood cell counts, CNS infiltration, and bulky extramedullary leukemia.
  • Median event-free survival was 4 months, and median survival was 11 months.
  • Cell lines derived showed T-lymphoblastic or myeloid characteristics.

Conclusions:

  • The t(8;14)(q24;q11) translocation defines an aggressive leukemia/lymphoma subtype in children.
  • Common features include high tumor burden, early extramedullary spread, and poor prognosis.
  • This subtype shares characteristics with other T-ALLs involving 13(q11).