Jove
Visualize
Contact Us

Related Experiment Videos

[Apolipoprotein C-III in nephrology].

Z A Massy1, B Lacour

  • 1INSERM U90, Paris.

Presse Medicale (Paris, France : 1983)
|June 6, 1992
PubMed
Summary
This summary is machine-generated.

Elevated apolipoprotein C-III (apoC-III) levels in kidney disease patients correlate with hypertriglyceridemia. Understanding apoC-III metabolism is key to addressing lipid disorders in renal failure.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to the Letter to the Editor Entitled "Optimizing Furosemide Use in Advanced CKD: Balancing Risks and Benefits".

Kidney international reports·2025
Same author

Wireless phone use in childhood and adolescence and neuroepithelial brain tumours: Results from the international MOBI-Kids study.

Environment international·2022
Same author

Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease: a cross-sectional study from the CKD-REIN cohort study.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2019
Same author

Mortality due to bleeding, myocardial infarction and stroke in dialysis patients.

Journal of thrombosis and haemostasis : JTH·2018
Same author

[Use of wireless telecommunications technologies among the 10-25-year-old in France: Data extracted from the French part of the MOBI-KIDS study].

Revue d'epidemiologie et de sante publique·2018
Same author

Geographical variability in survival of European children with central nervous system tumours.

European journal of cancer (Oxford, England : 1990)·2017
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biochemistry
  • Nephrology
  • Lipid Metabolism

Context:

  • Apolipoprotein C-III (apoC-III) is a protein synthesized in the liver and small intestine.
  • It plays a role in regulating triglyceride levels by inhibiting lipoprotein lipase and hepatic triglyceride lipase.
  • Increased plasma apoC-III levels are observed in patients with renal failure, on hemodialysis, and post-renal transplant.

Purpose:

  • To discuss the role of hormonal and non-hormonal factors in modulating apolipoprotein C-III metabolism.
  • To elucidate the physiopathological mechanisms underlying lipid disorders in renal diseases.

Summary:

  • Apolipoprotein C-III (apoC-III) is synthesized by the liver and small intestine and inhibits key lipases.
  • Elevated plasma apoC-III levels are a characteristic finding in patients with chronic kidney disease, undergoing hemodialysis, or having received a renal transplant.

Related Experiment Videos

  • This elevation is strongly associated with the hypertriglyceridemia commonly seen in these patient populations.

    • Impact:

    • Provides insights into the mechanisms of dyslipidemia in renal disease.
    • Highlights apolipoprotein C-III as a potential therapeutic target for managing hypertriglyceridemia in kidney patients.
    • Contributes to a better understanding of lipid metabolism alterations in the context of kidney dysfunction.