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The bactericidal activity and postantibiotic effect of trospectomycin
B H Yagi1, R D Schaadt, G E Zurenko
1Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan.
Diagnostic Microbiology and Infectious Disease
|July 1, 1992
Summary
Trospectomycin sulfate (TRS) exhibits species-dependent bactericidal and bacteriostatic activity. This novel antibiotic demonstrates a broad-spectrum postantibiotic effect, suggesting unique clinical potential.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Trospectomycin sulfate (TRS) is a novel, broad-spectrum aminocyclitol antibiotic.
- TRS is under clinical development for various infections, including respiratory tract infections, bacterial vaginosis, pelvic inflammatory disease, and gonorrhea.
Purpose of the Study:
- To investigate the bactericidal activity of TRS using time-kill kinetics.
- To determine the postantibiotic effect (PAE) of TRS against a panel of bacterial pathogens.
Main Methods:
- Time-kill kinetic assays were performed to assess bactericidal activity.
- Postantibiotic effect (PAE) was measured after a 1-hour exposure to TRS at four times the minimum inhibitory concentration or 32 µg/ml.
Main Results:
- TRS displayed species-dependent activity: bacteriostatic against Staphylococcus epidermidis, Enterococcus faecalis, and Escherichia coli; bactericidal against Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella catarrhalis, and Bacteroides fragilis.
- Significant PAE values were observed for TRS, ranging from 1.5 to over 6.7 hours, depending on the bacterial species.
Conclusions:
- Trospectomycin sulfate exhibits both bacteriostatic and bactericidal properties.
- The broad-spectrum postantibiotic effect of TRS is notable and potentially advantageous compared to other antibiotics.