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Lp(a): a link between thrombosis and atherosclerosis
1Department of Medicine, Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
European Journal of Epidemiology
|May 1, 1992
Summary
Lipoprotein(a) (Lp(a)) is a particle similar to LDL cholesterol but with a unique protein structure. This structure makes Lp(a) a potent contributor to cardiovascular disease by promoting both atherosclerosis and thrombosis.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Molecular Biology
Background:
- Lipoprotein(a) (Lp(a)) is an LDL-like particle.
- Lp(a) comprises ApoB-100 linked to apo(a), a plasminogen-like glycoprotein.
- Lp(a) possesses both atherogenic and thrombogenic properties.
Purpose of the Study:
- To elucidate the pathogenic mechanisms of Lp(a).
- To compare the cardiovascular risk posed by Lp(a) versus LDL.
Main Methods:
- Biochemical analysis of Lp(a) structure.
- Functional assays for atherogenicity and thrombogenicity.
Main Results:
- Lp(a) exhibits dual pro-atherosclerotic and pro-thrombotic activities.
- These activities are likely synergistic, enhancing Lp(a)'s pathogenicity.
Conclusions:
- Lp(a) is a significant cardiovascular pathogen.
- On a molar basis, Lp(a) poses a greater cardiovascular risk than LDL.