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Lp(a): a link between thrombosis and atherosclerosis
1Department of Medicine, Biochemistry and Molecular Biology, University of Chicago, Illinois 60637.
European Journal of Epidemiology
|May 1, 1992
Abstract:
Lipoprotein(a), or Lp(a), is a lipoprotein having lipid composition similar to that of LDL, but a protein moiety consisting of ApoB 100 linked by disulfide bridge to apo(a), a glycoprotein with structural similarity to plasminogen. Lp(a) can be both atherogenic and thrombogenic. These two actions are likely to be mutually operative, a fact that on a molar basis makes Lp(a) more of a cardiovascular pathogen than LDL.