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Excitatory 5-HT2-mediated effects on rostral ventrolateral medullary neurones in rats
1Department of Physiology, The Medical School, Birmingham, UK.
Abstract:
Iontophoretic application of the 5-HT2 receptor agonist alpha-methyl-5-HT excited 41 neurones in the rostral ventrolateral medulla, including a population of barosensitive cells. At high ejecting currents (greater than 2-3 x threshold) the excitation was replaced by an inhibition. The excitatory responses evoked by low doses of alpha-methyl-5-HT were reduced during iontophoretic application of ketanserin (2-5 nA) in 8/9 cells. alpha-Methyl-5-HT inhibited ongoing activity of a further 28 cells. The inhibitions were not blocked by ketanserin (n = 3). We suggest that alpha-methyl-5-HT exerts an excitatory 5-HT2-mediated effect on neurones in the rostral ventrolateral medulla.