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Updated: Sep 22, 2026

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
Published on: October 20, 2023
[Interventional radiology in the treatment of acute and chronic mesenteric ischemia]
G Simonetti1, L Lupattelli, F Urigo
1Istituto di Radiologia, II Università di Roma Tor Vergata.
Insights
Percutaneous transluminal angioplasty (PTA) and fibrinolysis offer effective radiologic revascularization for visceral artery diseases. These minimally invasive treatments show high success rates for acute and chronic mesenteric ischemia, providing a valuable alternative to surgery.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Gastroenterology
Background:
- Visceral artery stenoses and occlusions pose significant clinical challenges.
- Surgical intervention carries inherent risks for treating these conditions.
Purpose of the Study:
- To evaluate the efficacy of radiologic revascularization, specifically percutaneous transluminal angioplasty (PTA) and fibrinolysis, for visceral artery diseases.
- To assess treatment outcomes for patients with acute and chronic mesenteric ischemia.
Main Methods:
- Retrospective analysis of 32 patients with visceral artery conditions.
- Treatment modalities included PTA (using Grüntzig, Cobra, or Simmons balloons) and fibrinolysis (urokinase or rtPA).
- Papaverine infusion was used for non-occlusive acute mesenteric ischemia.
Main Results:
- Successful treatment in 80% of acute mesenteric ischemia cases, with 4 out of 5 patients experiencing symptom remission.
- PTA achieved a technical success rate of 85-95% in 22 patients with chronic mesenteric ischemia.
- A 10% restenosis rate was observed at 24 months for chronic cases.
Conclusions:
- Radiologic revascularization, including PTA and fibrinolysis, is a highly effective treatment for visceral artery stenoses and occlusions.
- These minimally invasive procedures offer excellent therapeutic results and can be widely applied.
- PTA, potentially combined with loco-regional fibrinolytic therapy, represents a valuable alternative to surgery.
Abstract:
Radiologic revascularization procedures--i.e., percutaneous transluminal angioplasty (PTA) and fibrinolysis--are a valuable alternative to surgery in the treatment of stenoses and occlusions of the visceral vessels, that is the celiac tripod and the superior and inferior mesenteric arteries. We treated 32 patients, 10 of them with acute mesenteric ischemia and 22 with chronic mesenteric ischemia and clinical signs of angina abdominis. Grüntzig or pre-shaped Cobra or Simmons balloons were employed (diameter: 5-7 mm, with variable length) when PTA was performed. Urokinase or rtPA was employed for fibrinolysis. In 3 cases acute mesenteric ischemia was not occlusive and could be successfully treated with papaverine infusion. In 7 cases, acute mesenteric ischemia was occlusive: in 5 of these patients it was successfully treated by PTA and/or fibrinolysis. Our results were positive in 80% of the cases, with remission of clinical signs in 4 of 5 patients treated for acute mesenteric ischemia. In 22 patients with chronic mesenteric ischemia, 26 stenotic occlusions were observed at angiography and 22 were treated with PTA, which was technically successful in 21 instances (early success rate: 85-95%). At 24 months, 10% of restenosis was observed. In our experience, PTA of the visceral district, possibly preceded by loco-regional infusion of fibrinolytic drugs, can be widely applied and yields excellent therapeutic results.
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