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Ondansetron does not affect alfentanil-induced ventilatory depression or sedation
M Dershwitz1, P M Di Biase, C E Rosow
1Department of Anesthesia, Massachusetts General Hospital, Boston 02114.
Anesthesiology
|September 1, 1992
Summary
Ondansetron did not alter alfentanil-induced sedation or ventilatory depression in healthy volunteers. This study found no significant interaction between ondansetron and opioid effects on breathing or alertness.
Area of Science:
- Anesthesiology and Pharmacology
- Neuroscience
Background:
- Ondansetron is a 5-hydroxytryptamine type 3 receptor antagonist used for nausea and vomiting.
- The interaction between ondansetron and opioids, specifically on respiratory and sedative effects, is not well-documented.
Purpose of the Study:
- To investigate the effects of ondansetron on alfentanil-induced ventilatory depression and sedation.
- To assess potential modifications of opioid actions by a serotonin antagonist.
Main Methods:
- Healthy male volunteers received alfentanil infusion.
- Ventilatory drive was measured using the Read rebreathing technique.
- Sedation was assessed via visual analog scales.
- Ondansetron or placebo was administered in a randomized, double-blind manner.
Main Results:
- Alfentanil caused significant ventilatory depression and sedation in all participants.
- Neither ondansetron nor placebo administration altered the intensity of alfentanil's effects.
- Recovery from ventilatory depression and sedation after alfentanil discontinuation was similar across groups.
Conclusions:
- Ondansetron does not significantly affect alfentanil-induced sedation or ventilatory depression.
- The administration of ondansetron does not appear to modify key opioid-induced central nervous system effects.