Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enterococcus species in urinary tract infection.

D Felmingham1, A P Wilson, A I Quintana

  • 1Department of Clinical Microbiology, University College Hospital, London, United Kingdom.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|August 1, 1992
PubMed
Summary

Enterococcus species are increasingly causing urinary tract infections. Teicoplanin shows promise for treating these infections, as all tested strains were susceptible.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Collecting the data but missing the point: validity of hand hygiene audit data.

The Journal of hospital infection·2015
Same author

Use of XTT for quantitating clonogenic growth in soft agar.

Cytotechnology·2012
Same author

The methylene blue colorimetric microassay for determining cell line response to growth factors.

Cytotechnology·2012
Same author

Identification of risk factors by systematic review and development of risk-adjusted models for surgical site infection.

Health technology assessment (Winchester, England)·2011
Same author

The classification of soluble silicates for eye hazard using the enucleated rabbit eye test.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

In vitro activity of fusidic acid and mupirocin against coagulase-positive staphylococci from pets.

The Journal of antimicrobial chemotherapy·2008

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Enterococcus species are a significant cause of nosocomial urinary tract infections.
  • Urinary tract infections (UTIs) due to Enterococcus have shown a steady increase in prevalence since 1971.
  • Factors such as increased catheterization and broad-spectrum antibiotic use likely contribute to this rise.

Purpose of the Study:

  • To analyze the trends in Enterococcus species isolation from urinary samples.
  • To determine the antibiotic susceptibility patterns of Enterococcus isolates, with a focus on glycopeptides.
  • To evaluate the potential of teicoplanin as a treatment option for enterococcal UTIs.

Main Methods:

  • Prospective recording of significant urinary isolates since 1971.

Related Experiment Videos

  • Identification of Enterococcus species and determination of antibiotic susceptibilities.
  • Breakpoint susceptibility testing for vancomycin and teicoplanin on 1988 isolates.

    • Main Results:

    • Isolation of Enterococcus species increased from 4% (1971) to 12.6% (1990) in hospitals and 2% to 5.6% in general practice.
    • All Enterococcus species isolates remained sensitive to ampicillin.
    • Teicoplanin (2 µg/mL) inhibited all 526 tested strains, while vancomycin inhibited only 70%.

    Conclusions:

    • The rising prevalence of enterococcal UTIs necessitates effective treatment strategies.
    • Teicoplanin demonstrates potent in vitro activity against Enterococcus species relevant to UTIs.
    • Teicoplanin's high urinary levels suggest its potential as an alternative therapeutic agent for enterococcal UTIs.