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Medical laser mass spectrometric standardless microanalysis.

N E Benyaev, I M Arefiev

    Medical Progress Through Technology
    |January 1, 1992
    PubMed
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    Laser mass spectrometry enables standardless elemental analysis of biological samples. This method, dependent on laser power density, is effective for medical and toxicological diagnostics.

    Area of Science:

    • Analytical Chemistry
    • Biophysics

    Background:

    • Standardless elemental analysis is crucial for medical and biological sample characterization.
    • Laser mass spectrometry offers a potential method for such analyses.

    Purpose of the Study:

    • To investigate the application of laser mass spectrometry for standardless elemental analysis of medical and biological samples.
    • To demonstrate the feasibility of using laser ionization for quantitative elemental analysis without standards.

    Main Methods:

    • Review of laser emission interaction with target substances and ion formation.
    • Application of laser mass spectrometry on the EMAL-2 device for analyzing biological samples.
    • Analysis of liver tissue and whole blood samples without prior organic component removal.

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    Main Results:

    • Demonstrated the feasibility of standardless elemental analysis using laser mass spectrometry.
    • Identified laser emission power density as a critical parameter for successful analysis.
    • Presented mass spectra of unprocessed biological samples (liver tissue, whole blood).

    Conclusions:

    • Laser mass spectrometry is a viable technique for standardless elemental analysis of medical and biological samples.
    • The method is applicable to sanitary, hygienic, toxicological, and diagnostic tasks.
    • Analysis of microelemental composition changes in tissues and biological fluids is substantiated.