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Synthesis and pharmacological study of some 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones
S Plescia1, G Daidone, D Raffa
1Dipartimento di Chimica e Technologie Farmaceutiche, Università di Palermo, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|April 1, 1992
Abstract:
A number of new 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones was prepared and tested, together a few analogues previously obtained, for their analgesic, antipyretic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effects. In the carrageenan rat foot edema model one of the tested compounds showed activity and LD50 comparable to that of ASA, but the ulceration index approximated zero value.