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Bioactive polymers. 70. The kinetics of controlled release of neomycin in an alkaline medium
S Dumitriu1, N Aelenei, I M Popa
1Polytechnic Institute of Jassy, Romania.
Abstract:
Neomycin is coupled on xanthan--a polysaccharide of microbial biosynthesis produced by Xanthomona campestris--through ionic complexation. The kinetics of neomycin release, in vitro, at pH = 8.2 is studied. A release of neomycin, following a zero order kinetics, is observed, regardless of the eluent flow-rate. The neomycin-xanthan complex, protected by a cellulosic membrane, behaves like a monolithic-type device. Diffusion coefficients--increasing with increasing the eluent flow-rate--are also calculated.