Related Experiment Videos
Virally induced immunosuppression
R M Zinkernagel1, H Hengartner
1University of Zurich, Switzerland.
Current Opinion in Immunology
|August 1, 1992
Abstract:
A mouse model of virus-triggered, T-cell mediated acquired immunosuppression is analyzed. Lymphocytic choriomeningitis virus initially infects mostly macrophages and antigen-presenting cells; these are destroyed by lymphocytic choriomeningitis virus specific cytotoxic T cells resulting in immunosuppression. Similar immunopathological mechanisms may play a role in acquired immune deficiency syndrome.