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Zidovudine prophylaxis after accidental exposure to HIV: the Italian experience. The Italian Study Group on
V Puro1, G Ippolito, E Guzzanti
1Unità Operativa AIDS RM 10, Ospedale Lazzaro Spallanzani, Roma, Italy.
Objectives:
To evaluate the use of zidovudine prophylaxis in HIV-exposed health-care workers (HCW) in Italy and to determine its short-term toxicity.
Design:
Longitudinal, open study with retrospective and prospective collection of data.
Setting:
All Italian clinical centres that care for HIV-infected patients and are licensed by the Ministry of Health to dispense zidovudine and 30 hospitals participating in the Italian Multicentre Study on Occupational Risk of HIV Infection.
Study Population:
HCW and other individuals who accepted zidovudine prophylaxis after accidental exposure to HIV.
Results:
Data were collected for 224 HIV-exposed individuals until 30 June 1991. An increase in zidovudine prophylaxis was observed. All but 10 subjects received 1000-1250 mg zidovudine per day. Anaemia (five cases), neutropenia (one case) and an increase in serum alanine aminotransferase levels (two cases) were the only haematochemical side-effects observed; none of the subjects ceased prophylaxis because of side-effects. More than 50% of subjects had constitutional reactions; as a result, prophylaxis was stopped by 29 patients. These adverse effects began within 10 days of prophylaxis; all resolved after prophylaxis was stopped. No HIV-antibody seroconversions were observed after a mean follow-up of 8 months.
Conclusions:
Zidovudine prophylaxis has become a feature of the management of occupational exposures to HIV in health-care settings; short-term toxicity is mild, dose-related and reversible. Further studies are needed to assess the risk of long-term sequelae.