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Measurements of T1 and T2 over time in formalin-fixed human whole-brain specimens
1Department of Diagnostic Radiology, Akademiska Sjukhuset, Uppsala University, Sweden.
Acta Radiologica (Stockholm, Sweden : 1987)
|September 1, 1992
Abstract:
T1 and T2 were measured in 5 formalin-fixed human whole-brain specimens as a function of time. Gray matter/white matter contrast reversal was observed around the 4th day and was considered to be due to the greater decrease in T1 in gray than in white matter. A possible explanation for this is that the decomposition of the myelin phospholipid structure by formalin somewhat counteracts the general reductive effect of the fixation procedure on relaxation times.