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Related Experiment Videos

Circulating endothelin in acute ischaemic syndromes.

S G Ray1, J J McMurray, J J Morton

  • 1Department of Cardiology, Western Infirmary, Glasgow, UK.

British Heart Journal
|May 1, 1992
PubMed
Summary

Plasma endothelin levels are elevated in chronic heart failure and after acute myocardial infarction, but not in angina. Following myocardial infarction, endothelin rises while atrial natriuretic factor decreases, suggesting a complex role in ischemic heart disease.

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Nephrology

Background:

  • Endothelin, a potent vasoconstrictor, may contribute to acute myocardial ischemia pathogenesis.
  • Atrial natriuretic factor acts as an endogenous antagonist to endothelin.
  • Investigating circulating endothelin patterns in ischemic heart disease is crucial.

Purpose of the Study:

  • To determine the pattern and significance of circulating endothelin in ischemic heart disease.
  • To compare endothelin concentrations in controls and patients with stable angina, unstable angina, acute myocardial infarction, and chronic heart failure.
  • To examine the relationship between endothelin and atrial natriuretic factor post-myocardial infarction.

Main Methods:

  • Studied 18 acute myocardial infarction, 10 unstable angina, 10 stable angina, 12 chronic cardiac failure patients, and 10 controls.

Related Experiment Videos

  • Measured venous plasma endothelin concentrations using radioimmunoassay.
  • Simultaneously measured endothelin and atrial natriuretic factor in acute myocardial infarction patients at set intervals.

    • Main Results:

    • Elevated mean endothelin concentrations were observed in chronic heart failure (13.83 fmol/ml) and acute myocardial infarction (peaking at 11.88 fmol/ml at 4 hours).
    • Endothelin levels were not significantly different in stable (6.56 fmol/ml) or unstable angina (6.41 fmol/ml) compared to controls (5.72 fmol/ml).
    • In acute myocardial infarction, atrial natriuretic factor levels were low (8.4 pg/ml at 1 hour) when endothelin was high.

    Conclusions:

    • Plasma endothelin is elevated in chronic heart failure and post-acute myocardial infarction, but not in stable or unstable angina.
    • Post-myocardial infarction, elevated endothelin coincides with reduced atrial natriuretic factor.
    • Further research is needed to elucidate endothelin's role in acute myocardial infarction and its interactions with other factors.