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Ocular hypotensive effects of medifoxamine
British Journal of Clinical Pharmacology
|September 1, 1992
Summary
Medifoxamine, an antidepressant, was found to significantly lower intraocular pressure and cause miosis in human volunteers. Its ocular hypotensive effects were less potent than timolol.
Area of Science:
- Pharmacology
- Ophthalmology
- Neuroscience
Background:
- Medifoxamine is a novel antidepressant drug.
- It selectively inhibits dopamine reuptake.
- Monoamine reuptake inhibitors are used to treat depression.
Purpose of the Study:
- To investigate the ocular effects of Medifoxamine.
- To determine if Medifoxamine reduces intraocular pressure.
- To assess the potential of Medifoxamine in ophthalmic applications.
Main Methods:
- Human volunteer studies were conducted.
- Single oral doses of Medifoxamine (300-1000 mg) were administered.
- Ocular parameters including intraocular pressure and pupil size were measured.
Main Results:
- Medifoxamine significantly reduced intraocular pressure.
- A small but statistically significant miosis was observed.
- The ocular hypotensive effect was less than that of oral timolol 20 mg.
Conclusions:
- Medifoxamine exhibits ocular hypotensive and miotic properties.
- These findings suggest potential applications in ophthalmology.
- Further research is warranted to explore Medifoxamine's ophthalmic utility.
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