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Diffusion of cloxacillin into synovial tissue.
H Mattie1, S De Marie, G Slaghuis
1University Hospital, Department of Infectious Diseases, Leiden, The Netherlands.
British Journal of Clinical Pharmacology
|September 1, 1992
Summary
Cloxacillin distributes rapidly into hip joint synovial tissue after intravenous infusion, with a mean distribution half-life of 22 minutes. This antibiotic achieves significant free drug concentrations in the tissue, crucial for infection treatment.
Area of Science:
- Pharmacokinetics
- Infectious Diseases
- Orthopedic Surgery
Background:
- Cloxacillin is a key antibiotic for treating bacterial infections.
- Understanding antibiotic distribution in synovial tissue is vital for effective orthopedic infection management.
Purpose of the Study:
- To determine the distribution kinetics of cloxacillin in human synovial tissue.
- To estimate the concentration of free cloxacillin in synovial fluid.
Main Methods:
- Intravenous infusion of 1g cloxacillin in 11 patients undergoing hip replacement.
- Measurement of antibiotic concentrations in plasma and synovial tissue samples.
- Estimation of distribution rate constants assuming passive distribution.
Main Results:
- The mean half-life of cloxacillin distribution into synovial tissue was 22 minutes.
- Estimated free drug concentration in synovial tissue was 77% of total tissue concentration.
- Predicted time to maximum tissue drug concentration after bolus dose was approximately 37 minutes.
Conclusions:
- Cloxacillin demonstrates rapid distribution into synovial tissue following intravenous administration.
- Achieved tissue concentrations suggest potential efficacy for treating orthopedic infections.