Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Capillary circulation in the brain.

W Kuschinsky1, O B Paulson

  • 1Department of Physiology, University of Heidelberg, Germany.

Cerebrovascular and Brain Metabolism Reviews
|January 1, 1992
PubMed
Summary

Brain capillary density correlates with local blood flow and metabolism. Current theories on capillary cycling and recruitment may stem from artifacts, suggesting a need for precise terminology like "erythrocyte recruitment."

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of electroconvulsive therapy on neural response to affective pictures: A randomized, sham-controlled fMRI study.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2018
Same author

Effects of erythropoietin on memory-relevant neurocircuitry activity and recall in mood disorders.

Acta psychiatrica Scandinavica·2016
Same author

Neural correlates of improved executive function following erythropoietin treatment in mood disorders.

Psychological medicine·2016
Same author

Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression.

Acta psychiatrica Scandinavica·2015
Same author

Cognitive profiles and regional cerebral blood flow patterns in dementia of the Alzheimer type.

European journal of neurology·2013
Same author

Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first-degree relatives of patients with depression.

Psychological medicine·2013

Area of Science:

  • Neuroscience
  • Physiology
  • Microcirculation

Background:

  • Local capillary density in brain structures is closely linked to blood flow and metabolism.
  • Capillary density development is influenced by local functional demands.
  • Previous research suggested capillary cycling and recruitment theories.

Purpose of the Study:

  • To investigate the relationship between capillary density, blood flow, and metabolism in the brain.
  • To re-evaluate existing theories of capillary cycling and recruitment.
  • To propose precise terminology for capillary perfusion phenomena.

Main Methods:

  • Analysis of single capillary perfusion.
  • Review of indirect evidence for perfusion heterogeneity.
  • Evaluation of factors influencing capillary diffusion capacity.

Main Results:

  • All brain capillaries are perfused with plasma at any given time.
  • Capillary cycling and recruitment theories may be based on experimental artifacts.
  • Evidence suggests heterogeneity in erythrocyte flow within capillaries under normal conditions.

Conclusions:

  • Capillary diffusion capacity is influenced by capillary surface area and perfusion rate homogenization.
  • Homogenizing perfusion rates can create an "apparent" increase in capillary surface area.
  • Recommended precise terms: "recruitment of erythrocytes" and "recruitment of previously nonperfused capillaries".

Related Experiment Videos