Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin D analogues and psoriasis.

J Berth-Jones1, P E Hutchinson

  • 1Department of Dermatology, Leicester Royal Infirmary, U.K.

The British Journal of Dermatology
|August 1, 1992
PubMed
Summary

Topical vitamin D analogues like calcitriol and calcipotriol are effective, safe treatments for psoriasis vulgaris. These compounds regulate skin cell growth and immune responses, offering a convenient therapeutic option.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

British Association of Dermatologists guidelines for the management of people with rosacea 2021.

The British journal of dermatology·2021
Same author

British Association of Dermatologists guidelines for the safe and effective prescribing of oral ciclosporin in dermatology 2018.

The British journal of dermatology·2019
Same author

Fatal toxic epidermal necrolysis: A complication of vancomycin treatment for an infected hip arthroplasty.

Hip international : the journal of clinical and experimental research on hip pathology and therapy·2017
Same author

Ivermectin cream improves health-related quality of life in patients with rosacea: data from a randomized trial.

The British journal of dermatology·2016
Same author

Maintenance of remission following successful treatment of papulopustular rosacea with ivermectin 1% cream vs. metronidazole 0.75% cream: 36-week extension of the ATTRACT randomized study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2015
Same author

Superiority of ivermectin 1% cream over metronidazole 0·75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial.

The British journal of dermatology·2014

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Psoriasis vulgaris is a chronic inflammatory skin condition.
  • Current treatments have limitations in efficacy, tolerability, or convenience.

Purpose of the Study:

  • To evaluate the efficacy and safety of topical vitamin D analogues for psoriasis treatment.
  • To explore the mechanism of action of these compounds.

Main Methods:

  • Clinical trials assessing calcitriol and calcipotriol efficacy.
  • Comparative studies against established psoriasis treatments.
  • Investigation of cellular and immunological effects.

Main Results:

  • Topical vitamin D analogues demonstrate significant efficacy in treating psoriasis vulgaris.
  • Calcipotriol shows comparable or superior results to betamethasone valerate and dithranol.
  • Potential mechanisms involve keratinocyte regulation and immune modulation.

Conclusions:

  • Topical vitamin D analogues represent a valuable, well-tolerated therapeutic option for psoriasis.
  • Further research into their complex mechanisms of action is warranted.
  • Careful monitoring is advised to prevent potential side effects like hypercalcemia.

Related Experiment Videos