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Granulomatous hypersensitivity to protamine as a complication of insulin therapy
M M Hulshof1, W R Faber, W F Kniestedt
1Department of Dermatology, Eemland Hospital, Amersfoort, The Netherlands.
The British Journal of Dermatology
|September 1, 1992
Abstract:
A patient is described who developed a granulomatous skin reaction to injections of protamine-insulin for the treatment of her diabetes mellitus. By means of skin testing it was shown that this reaction was caused by protamine. No adverse effects were seen when she was injected with insulin which did not contain protamine.