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Glucocorticoid receptors.

J W Funder1

  • 1Baker Medical Research Institute, Melbourne, Australia.

The Journal of Steroid Biochemistry and Molecular Biology
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Glucocorticoid hormones, crucial for circadian rhythms and stress, are regulated by ubiquitous receptors. Understanding these receptors and their interactions is key to a coherent physiology of glucocorticoid hormones.

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Physiology

Background:

  • Glucocorticoid hormones exhibit circadian variation and stress-induced elevation.
  • Glucocorticoid receptors (GR) are widely distributed, mediating diverse tissue-specific responses.
  • Type I (MR) and Type II (GR) receptor sites have complex roles, acting as mineralocorticoid or high-affinity glucocorticoid receptors.

Purpose of the Study:

  • Investigate factors modulating glucocorticoid receptor occupancy.
  • Determine specific response elements for Type I and II receptors.
  • Explore physiological roles of Type I high-affinity glucocorticoid receptors.
  • Examine evidence for glucocorticoid receptors beyond classical GR and MR.

Main Methods:

  • Review of existing literature on glucocorticoid secretion and action.

Related Experiment Videos

  • Analysis of factors influencing receptor occupancy (extracellular and intracellular).
  • Examination of receptor-specific response elements.
  • Assessment of evidence for novel glucocorticoid receptor types.

    • Main Results:

    • Glucocorticoid receptors are a final common pathway for circadian and stress responses.
    • Cell and tissue specificity is determined by pre-receptor, receptor, and genomic factors.
    • A coherent physiology of glucocorticoid hormones is becoming increasingly possible.

    Conclusions:

    • Glucocorticoid hormones and their receptors play a central role in physiological regulation.
    • Tissue-specific responses are governed by complex interactions at multiple levels.
    • Further research can elucidate the complete physiology of glucocorticoid hormones.