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Multiple fractions in the treatment of head and neck cancer
1Radiotherapy Department, North Staffordshire Royal Infirmary, Stoke-on-Trent, UK.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|September 1, 1992
Abstract:
Fifty-eight cases of head and neck cancer received hyperfractionated accelerated radiotherapy, with treatment three times daily to 47.5-54 Gy over 12-20 days. A total of 69% had a complete response within 3 months, and the actuarial survival was 52% at 1 year, 41% at 2 years, 43% at 3 years and 38% at 4 years. Acute reactions were rather more pronounced (31%) and late necrosis (15%) was more than would be expected with conventional fractionation. It is suggested that multiple fractions carried out by a small centre, are feasible and will reduce hospital stay.