Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surfactant administration and the cerebral circulation.

L Skov1, A Bell, G Greisen

  • 1Department of Neonatalogy, University Hospital Rigshospitalet, Copenhagen, Denmark.

Biology of the Neonate
|January 1, 1992
PubMed
Summary

Surfactant therapy in infants can temporarily decrease EEG activity, but cerebral blood flow is generally maintained. This suggests that factors other than cerebral ischemia cause the brief electrophysiologic disturbances observed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parent-Reported Health and Neurodevelopment in Children Who Were Mechanically Ventilated in Infancy.

Acta paediatrica (Oslo, Norway : 1992)·2025
Same author

<i>Staphylococcus pseudintermedius</i> isolated from atopic dogs with pyoderma induces mast cell degranulation.

New Zealand veterinary journal·2025
Same author

The mental health impacts of catastrophic events: policy considerations.

Perspectives in public health·2025
Same author

Corrigendum to "Assessing evidence-based practice among Australian radiographers: a self-report survey" [Radiography 30 (2) (March 2024) P696-P701].

Radiography (London, England : 1995)·2025
Same author

Enhancing evidence-based practice in radiography education: Evaluation of an applied curriculum intervention.

Radiography (London, England : 1995)·2024
Same author

Assessing evidence-based practice among Australian radiographers: A self-report survey.

Radiography (London, England : 1995)·2024

Area of Science:

  • Neonatal physiology
  • Cerebral circulation
  • Respiratory distress syndrome

Background:

  • Surfactant therapy is crucial for treating respiratory distress syndrome in preterm infants.
  • The impact of surfactant administration on cerebral hemodynamics and electrophysiologic activity requires further elucidation.

Purpose of the Study:

  • To investigate the effects of surfactant therapy on cerebral blood flow and electroencephalogram (EEG) activity in neonates.
  • To determine the relationship between hemodynamic changes and EEG depression following surfactant administration.

Main Methods:

  • Utilized near-infrared spectroscopy (NIRS) in 21 infants and xenon clearance technique in 13 infants to measure cerebral blood flow.
  • Monitored amplitude-integrated EEG, mean arterial blood pressure, and central venous/oesophageal pressure in all 34 participants.

Related Experiment Videos

Main Results:

  • A transient depression in EEG activity, lasting 10-20 minutes, was observed post-surfactant administration.
  • Cerebral blood volume and cerebral blood flow were largely maintained despite a decrease in mean arterial blood pressure.
  • No consistent correlation was found between blood pressure changes and EEG depression.

Conclusions:

  • Transient EEG disturbances after surfactant therapy are not primarily caused by cerebral ischemia.
  • Cerebral circulation is generally well-preserved during the acute phase of surfactant administration in neonates.
  • Further research is needed to identify the specific mechanisms underlying post-surfactant EEG changes.