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PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model
K Nho1, D Glower, S Bredehoeft
1Duke University Medical Center, Dept. of Surgery, Durham, NC 27710.
Abstract:
An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.