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Characterizing Mutational Load and Clonal Composition of Human Blood
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Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

Equilibration of isoagglutinins of human group O serum

J M SOLOMON

    Science (New York, N.Y.)
    |August 31, 1962
    PubMed

    Cross-reactive antibodies are shown to be responsibile for the difference in final levels of agglutination reached after dissociation of a centrifuged group O serum-erythrocyte mixture as compared with duplicate mixtures allowed toaggregate freely. This difference is seen only with certain group O sera, it is independent of complement, and it may be eliminated by absorption of the serum with A or B erythrocytes. The phenomenon is most likely the result of steric inhibition of smaller, cross-reactive antibodies in the aggregative system.

    Keywords:
    ANTIBODIESBLOOD GROUPS

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