Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Model for immunologic testing of biomaterials].

R Thull1, K Trautner, E J Karle

  • 1Lehrstuhl und Abteilung für Experimentelle Zahnmedizin Zahn-, Mund- und Kieferklinik Universität Würzburg.

Biomedizinische Technik. Biomedical Engineering
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxygen diffusion hardening of cp-titanium for biomedical applications.

Biomedical materials (Bristol, England)·2010
Same author

Nanostructured niobium oxide coatings influence osteoblast adhesion.

Journal of biomedical materials research. Part A·2006
Same author

Modified PMMA cements for a hydrolysis resistant metal-polymer interface in orthopaedic applications.

Acta biomaterialia·2006
Same author

[Electrochemical properties of biocompatible material hardness modifications on titanium and steel under mechanical loads].

Biomedizinische Technik. Biomedical engineering·2005
Same author

Alkali ion substituted calcium phosphate cement formation from mechanically activated reactants.

Journal of materials science. Materials in medicine·2005
Same author

Rheological enhancement of mechanically activated alpha-tricalcium phosphate cements.

Journal of biomedical materials research. Part B, Applied biomaterials·2005
Same journal

Spinal x-ray based scoliosis diagnosis using deep learning: a comparison of YOLOv11 and ResNet.

Biomedizinische Technik. Biomedical engineering·2026
Same journal

Transvaginal ultrasound-based radiomics and integrated clinical indicators via multimodal deep learning for prediction of endometrial polyp recurrence after hysteroscopic surgery.

Biomedizinische Technik. Biomedical engineering·2026
Same journal

Computed tomography imaging and observation of hemorrhage in traumatic splenic rupture pre and post partial splenectomy.

Biomedizinische Technik. Biomedical engineering·2026
Same journal

Automatic measurement of vertebral compression ratio on lumbar MR images fracture assessment based on MS-Res-AttU-Net model framework.

Biomedizinische Technik. Biomedical engineering·2026
Same journal

Early prediction of progressive cerebral contusion using a deep transfer learning-enhanced multimodal nomogram.

Biomedizinische Technik. Biomedical engineering·2026
Same journal

Enhancing prediction of basal ganglia hemorrhage expansion: a radiomic approach with texture analysis in computed tomography.

Biomedizinische Technik. Biomedical engineering·2026
See all related articles

Biomaterial corrosion and electric fields can alter proteins into antigens, triggering immune responses. A new biocompatibility index, based on protein adsorption, predicts material performance and may reduce animal testing.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Electrochemistry

Context:

  • Biomaterial implants can elicit immune responses due to corrosion products and surface electric fields.
  • These factors can modify proteins, transforming them into antigens recognized as foreign by the immune system.
  • Current methods lack ways to measure electric field strength near biomaterial surfaces.

Purpose:

  • To investigate how titanium surface double layers influence protein conformation and antigenicity.
  • To develop a biocompatibility index independent of surface area for predicting material performance.
  • To explore the potential of immunological tests to replace animal experiments.

Summary:

  • Corrosion products and electric fields convert proteins into antigens, initiating immune responses.

Related Experiment Videos

  • The study examined protein adsorption onto uncoated and coated titanium surfaces using 14C-labeled Bovine Serum Albumin.
  • A novel biocompatibility index was derived from the ratio of natural to adsorbed protein concentrations.

    • Impact:

    • The developed biocompatibility index correlates with material performance, confirmed by animal testing.
    • This research offers a new method for assessing biomaterial immunogenicity.
    • Findings suggest immunological assays could potentially replace traditional animal testing in the future.