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Updated: Aug 2, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
Published on: November 1, 2012
Hydration of DNA bases: analysis of crystallographic data
B Schneider1, D Cohen, H M Berman
1Department of Chemistry, Rutgers, State University of New Jersey, New Brunswick 08903.
Abstract:
We present a systematic analysis of water structure around nucleic acid bases. We have examined 28 crystal structures of oligonucleotides, and have studied the patterns of water around the four bases, guanine, cytosine, adenine, and thymine. The geometries of water positions were calculated up to 4.00 A from base atoms. We have found conformation-dependent differences in both the geometry and extent of hydration of the bases.
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