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Coeliac disease and collagenous colitis.
V N Perisic1, G Kokai, M Pavlovic
1Mother and Child Health Institute of Serbia, Yugoslavia.
The Italian Journal of Gastroenterology
|September 1, 1992
Summary
Both a father and daughter with chronic diarrhea and weight loss were diagnosed with celiac disease. While gluten-free diets improved symptoms, persistent colonic collagen deposition was noted in both patients.
Area of Science:
- Gastroenterology
- Immunology
- Genetics
Background:
- Celiac disease is an autoimmune disorder triggered by gluten ingestion, leading to small intestine damage.
- Chronic diarrhea, weight loss, and growth failure are common clinical manifestations.
- Collagenous colitis is a rare condition characterized by collagen deposition in the colon.
Observation:
- A familial pattern of celiac disease was observed in a father and daughter.
- Both presented with chronic watery diarrhea and failure to thrive or weight loss.
- The daughter was diagnosed with both celiac disease and collagenous colitis.
- The father exhibited colonic collagen deposition with inflammatory changes.
Findings:
- Both patients improved clinically on a gluten-free diet, confirming celiac disease.
- Despite clinical improvement, colonic collagen deposition persisted in both individuals.
- This suggests a potential link between celiac disease and colonic collagen deposition, even after gluten withdrawal.
Implications:
- Familial celiac disease warrants thorough gastrointestinal investigation in affected relatives.
- Persistent colonic collagen deposition may indicate a distinct or overlapping pathological process.
- Further research is needed to elucidate the relationship between celiac disease and collagenous conditions.