Related Experiment Video
Updated: Aug 14, 2026

Pentylenetetrazole-Induced Kindling Mouse Model
Published on: June 12, 2018
Phenytoin-induced IgG2 and IgG4 deficiencies in a patient with epilepsy
A Ishizaka1, M Nakanishi, E Kasahara
1Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Abstract:
A five-year-old girl with epilepsy and recurrent respiratory infections was investigated for serum IgG subclass concentrations. She was diagnosed as having a combined deficiency of IgG2 and IgG4 with a decreased serum concentration of IgA and IgG3 and was given replacement therapy with i.v. immunoglobulins. Since then, she has been free from respiratory infections. After phenytoin therapy was stopped, IgG subclass deficiency improved. This case describes the further action of phenytoin on the immune system, adding IgG subclass deficiency to the list.
Related Concept Videos
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Antiepileptic Drugs: GABAergic Pathway Potentiators
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for their...
Antiepileptic Drugs: Glutamate Antagonists
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Inborn Errors of Metabolism
Epilepsy ll: Types

