Allergic encephalomyelitis: rapid induction without the aid of adjuvants

Science (New York, N.Y.)
|August 9, 1963
PubMed

Rapid production of allergic encephalomyelitis has heretofore required injection of nervous tissue emulsified in immunologic adjuvants. Adjuvants are not required if large doses of a potent nervous-tissue anttigen and a highly susceptible strain of rats are used. Susceptibility was increased in animals inoculated beforehand with pertussis vaccine.