Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomal aberrations and schizophrenia. Autosomes.

A S Bassett1

  • 1Department of Psychiatry, University of Toronto, Ontario, Canada.

The British Journal of Psychiatry : the Journal of Mental Science
|September 1, 1992
PubMed
Summary

Chromosomal aberrations may indicate regions for schizophrenia susceptibility genes. Identifying these genetic links is crucial for understanding complex psychiatric disorders like schizophrenia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An online survey to understand the needs of caregivers of family members with 22q11 deletion syndrome.

Journal of intellectual disability research : JIDR·2023
Same author

The COVID-19 pandemic's impact on worry and medical disruptions reported by individuals with chromosome 22q11.2 copy number variants and their caregivers.

Journal of intellectual disability research : JIDR·2022
Same author

Neurocognition and adaptive functioning in a genetic high risk model of schizophrenia.

Psychological medicine·2018
Same author

A neurogenetic model for the study of schizophrenia spectrum disorders: the International 22q11.2 Deletion Syndrome Brain Behavior Consortium.

Molecular psychiatry·2017
Same author

Cerebral dopamine deficiency, plasma monoamine alterations and neurocognitive deficits in adults with phenylketonuria.

Psychological medicine·2017
Same author

Autism Spectrum and psychosis risk in the 22q11.2 deletion syndrome. Findings from a prospective longitudinal study.

Schizophrenia research·2017

Area of Science:

  • Genetics
  • Psychiatry
  • Molecular Biology

Background:

  • Schizophrenia's genetic underpinnings are complex and not fully understood.
  • Chromosomal abnormalities have been linked to various genetic illnesses, offering potential clues for gene localization.
  • Identifying specific chromosomal regions associated with schizophrenia is vital for gene discovery.

Purpose of the Study:

  • To review reported autosomal chromosomal abnormalities associated with psychotic disorders.
  • To assess the relevance of these abnormalities for linkage studies aiming to localize schizophrenia susceptibility genes.
  • To propose strategies for future research in detecting new chromosomal aberrations linked to major psychotic disorders.

Main Methods:

  • Systematic review of reported autosomal abnormalities in psychotic disorders.
  • Application of standardized criteria (specificity, diagnosis, family history, weight of evidence) to evaluate relevance for linkage studies.
  • Analysis of existing literature to identify potentially significant chromosomal regions.

Main Results:

  • Four chromosomal regions (5q, 11q, 18q, and 19p) were identified as 'possibly relevant' for schizophrenia linkage studies.
  • The review highlights the need for caution in interpreting associations due to the complex inheritance of psychiatric disorders.
  • Established criteria were used to prioritize chromosomal regions for further investigation.

Conclusions:

  • Chromosomal aberrations offer a valuable approach for identifying schizophrenia susceptibility genes.
  • The identified regions (5q, 11q, 18q, 19p) warrant further investigation in linkage studies.
  • Future research should focus on detecting novel chromosomal aberrations to advance the isolation of schizophrenia-related genes.

Related Experiment Videos