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Isoniazid and wound healing
Canadian Medical Association Journal
|February 2, 1963
Summary
Oral isoniazid effectively stimulates wound healing and granulation tissue formation in non-tuberculous patients. Topical isoniazid also benefits indolent skin ulcers, with combined therapy showing superior results for delayed wound healing.
Area of Science:
- Wound Healing Research
- Dermatology
- Pharmacology
Background:
- Delayed wound healing presents a significant clinical challenge.
- Indolent skin ulcers often resist conventional treatments.
- Antibiotic resistance necessitates novel therapeutic approaches.
Purpose of the Study:
- To evaluate the efficacy of isoniazid in promoting wound healing.
- To assess the effectiveness of topical isoniazid for indolent skin ulcers.
- To investigate the combined effect of oral and topical isoniazid in complex wound cases.
Main Methods:
- Administration of oral isoniazid (3 mg/kg) to patients with delayed wound healing.
- Application of a 2% topical isoniazid ointment in eucerin for indolent skin ulcers.
- Simultaneous use of oral and topical isoniazid in non-responsive cases.
Main Results:
- Oral isoniazid rapidly stimulated healthy granulation tissue formation and superior scar resistance.
- Topical isoniazid promoted rapid epithelialization in indolent skin ulcers.
- Combined therapy successfully treated wounds that failed to respond to antibiotics or isoniazid alone.
Conclusions:
- Isoniazid shows potential in accelerating wound healing and improving scar quality.
- Topical isoniazid is effective for indolent skin ulcers, enhancing epithelialization.
- Isoniazid may enhance host repair mechanisms, offering benefits in antibiotic-resistant infections.