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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study
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Antibody Binding Specificity for Kappa (Vκ) Light Chain-containing Human (IgM) Antibodies: Polysialic Acid (PSA) Attached to NCAM as a Case Study

Published on: June 29, 2016

Antigenicity of polypeptides: immunological unresponsiveness to copolymers of gamma-amino acids

P H MAURER, R LOWY, C KIERNEY

    Science (New York, N.Y.)
    |March 15, 1963
    PubMed

    Immunological tolerance toward three synthetic random copolymers of the alpha-amino acids, glutamic, lysine, alanine, and tyrosine, was produced by a single injection of the polymers into newborn rabbits. The tolerant state could be extended by an additional intravenous injection of antigen. Repeated injections of the polymer in adjuvant mixture could "break" the tolerant state.

    Keywords:
    ANTIGENSGLUTAMATES

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