[The effect of cyclophosphamide and methotrexate on gastric emptying and secretion in rats]

The effect of cyclophosphamide and methotrexate was studied in rats on the evacuation of 50% BaSO4 suspension from the stomach (doses: 50-200 mg.kg-1 and 5-20 mg.kg-1 s.c.) and on HCl secretion (doses: 100 mg.kg-1 and 10 mg.kg-1 s.c.) after stimulation with pentagastrin (25 micrograms.kg-1 s.c.). Both cytostatics were found to slow down gastric evacuation and to suppress the effect of pentagastrin on gastric secretion. The presented changes may relate to the adverse effects on the GIT observed in patients treated with the given cytostatics. (Fig. 4, Ref. 17.)