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Published on: September 11, 2013
Tumors induced in primates by chicken sarcoma virus
Science (New York, N.Y.)
|June 28, 1963
Summary
Newborn rhesus monkeys injected with Rous sarcoma virus developed fibrosarcomas, demonstrating oncogenesis in primates. Adult monkeys showed no tumor development, highlighting age-related susceptibility to viral oncogenesis.
Area of Science:
- Oncology
- Virology
- Primate research
Background:
- Rous sarcoma virus (RSV) is a known oncogenic retrovirus.
- Tumorigenesis in non-human primates is a critical area for understanding viral oncogenesis.
Purpose of the Study:
- To investigate the oncogenic potential of a Rous sarcoma virus variant in rhesus monkeys.
- To determine if sarcomas can be induced in primates via viral injection.
Main Methods:
- Injection of a Rous sarcoma virus suspension into adult and newborn rhesus monkeys.
- Tumor monitoring and diagnosis, including histopathological examination.
- Viral isolation and re-inoculation into chick wing-web assays to confirm viral presence.
Main Results:
- Seven out of eight newborn monkeys developed tumors within 2 to 6 weeks.
- Three of these tumors were histopathologically confirmed as fibrosarcomas.
- No tumors were observed in the four adult monkeys after 11 weeks.
- Virus was successfully demonstrated in two tumor samples via chick wing-web assay.
Conclusions:
- Rous sarcoma virus can induce fibrosarcomas in newborn rhesus monkeys.
- Newborn primates exhibit susceptibility to viral oncogenesis, unlike adults.
- This study represents the first documented instance of virus-induced sarcomas in primates.
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