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Published on: July 24, 2016
Adenoviruses types 3 and 5 isolated from the cerebrospinal fluid of children
Canadian Medical Association Journal
|November 24, 1962
Abstract:
Adenoviruses types 3 and 5 were isolated from the cerebrospinal fluid of two sick children. These agents were thought to be responsible for the neurological state of the children at the phase of illness when they were isolated. The possibility of mixed infections or of superimposed infections was considered since one was isolated following herpes zoster infection in the one child and the other following varicella. The role of adenoviruses as latent agents of potential pathogenicity is discussed.
Insights
Adenoviruses types 3 and 5 were isolated from cerebrospinal fluid in two children with neurological illness. These viral infections may contribute to neurological conditions, especially following other infections like varicella.
Area of Science:
- Virology
- Pediatric Neurology
- Infectious Diseases
Background:
- Adenoviruses are common viruses that can cause a range of illnesses.
- Neurological complications associated with viral infections in children are a significant concern.
- The potential for adenoviruses to cause severe neurological disease is not fully understood.
Purpose of the Study:
- To report the isolation of adenoviruses types 3 and 5 from cerebrospinal fluid of two children with neurological symptoms.
- To investigate the potential role of these adenoviruses in the children's neurological conditions.
- To discuss the implications of adenoviruses as latent agents in pediatric neurological diseases.
Main Methods:
- Cerebrospinal fluid samples were collected from two sick children.
- Adenoviruses types 3 and 5 were isolated from the cerebrospinal fluid.
- Clinical histories, including preceding infections like herpes zoster and varicella, were considered.
Main Results:
- Adenoviruses types 3 and 5 were identified in the cerebrospinal fluid of two children presenting with neurological illness.
- The isolation occurred during the acute phase of illness, suggesting a potential causal link.
- The possibility of co-infections or secondary infections was noted, given prior herpes zoster and varicella.
Conclusions:
- Adenoviruses types 3 and 5 may be implicated in causing neurological disease in children.
- The findings highlight the importance of considering adenoviruses in the differential diagnosis of pediatric neurological disorders.
- Further research is needed to understand the pathogenic potential and latency of adenoviruses in neurological infections.
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